hCEACAM6/MC-38
CBPG0193
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| I. Background | |
| CEACAM6 基因，全称癌胚抗原相关细胞黏附分子 6（Carcinoembryonic Antigen- Related Cell Adhesion Molecule 6），是人类 19 号染色体上的关键癌基因，编码一种免疫球 蛋白超家族跨膜糖蛋白。该蛋白主要表达于上皮源性肿瘤及髓系细胞表面，顺利获得介导不依 赖钙和纤连蛋白的细胞间黏附，在肿瘤进展中发挥重要作用。其机制涉及促进肿瘤细胞迁 移、侵袭及失巢凋亡抵抗，并调控上皮间质转化（EMT）和 Src/PI3K/Akt 信号通路，从而 增强癌细胞存活、转移和抗药性。结构上，CEACAM6 可顺利获得 Ig 样 V 型结构域形成同二聚 体，或与 CEACAM8 等分子异二聚化，进一步放大其促癌效应。此外，CEACAM6 还参与 中性粒细胞与内皮细胞的相互作用，影响肿瘤微环境中的炎症及免疫逃逸。 临床研究表明，CEACAM6 在肺癌、乳腺癌、结直肠癌等多种实体肿瘤中高表达，其 水平与肿瘤分期、分级及预后密切相关。高表达患者常伴随更高的复发风险和更低的生存 率，使其成为重要的癌症预后标志物及治疗靶点。 |
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| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | hCEACAM6 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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| V. In VIVO Data | |
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Index |
Content |
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Animal |
C57BL/6J, 7weeks, female |
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Implanted Position |
Subcutaneous (right flank region) |
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Injected Cell Numbers |
1×10^6/0.1ml |
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Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hCEACAM6/MC38 Mean Body Weight ± SEM.
2. Tumor Volume
Figure 3. hCEACAM6/MC38 Mean Tumor Volume ± SEM .
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
