hSTEAP1/MC-38
CBPG0164
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| I. Background | |
| 前列腺六跨膜上皮抗原 1（STEAP1），又称为 PRSS2，一种六次跨膜蛋白，具有 N 端和 C 端均在细胞内的结构，属于 STEAP 家族，该家族还包含成员 STEAP1B、STEAP2、 STEAP3、STEAP4。其中，STEAP1B 是 STEAP1 的截短同源物，是一个四次跨膜蛋白。 STEAP1 在前列腺上皮细胞中高表达，但在其他正常组织中表达较低，在前列腺癌、膀胱 癌、肺癌、乳腺癌等多种癌症中高表达。STEAP1 参与细胞内的氧化还原反应，可能在铁 代谢和细胞增殖中发挥作用。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | hSTEAP1 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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| V. In VIVO Data | |
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Index |
Content |
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Animal |
C57BL/6J, 7weeks, female |
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Implanted Position |
Subcutaneous (right anterior flank region) |
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Injected Cell Numbers |
1×10^6/0.1ml |
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Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hSTEAP1/MC38 Mean Body Weight ± SEM.
2. Tumor Volume
Figure 3. hSTEAP1/MC38 Mean Tumor Volume ± SEM.
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
