hERBB3(HER3)/MC-38
CBPG0036
询 价
留 言
产品描述
产品数据库
| I. Background | |
| ERBB3 又称 HER3（人表皮生长因子受体 3），是表皮生长因子受体 (EGFR/ERBB) 受体酪氨酸激酶家族的成员。该家族由四个成员组成：EGFR（表皮生长因子受体）、ErbB2 、ErbB3 和 ErbB4 。与 EGFR 不同的是，ErbB2 是一种无配体受体，而 ErbB3 缺乏酪 氨酸激酶活性。因此，ErbB2 和 ErbB3 仅在 ErbB 异二聚体环境中才有活性，而由 Nrg（神 经调节蛋白）配体驱动的 ErbB2-ErbB3 异二聚体是细胞生长和转化方面最普遍和最有效的 复合物。配体激活的 ErbB2-ErbB3 异二聚体信号传导效力的基础在于，这种二聚体能够非 常有效地发出信号，既可以顺利获得 Ras-ERK（细胞外信号调节激酶）途径进行增殖，也可以 顺利获得 PI3K-Akt/PKB（磷脂酰肌醇-3激酶-Akt/蛋白激酶-B）途径进行存活。此外，这种受体二聚体可以逃避下调机制，从而延长信号传导时间。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | ERBB3 |
| Stability: | 32 passages |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+5μg/ml Blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
|
Figure 1. Recombinant hERBB3/MC38 stably expressing ERBB3. |
|
| V. In VIVO Data | |
|
Index |
Content |
|
Animal |
C57BL/6J, 6weeks, female |
|
Implanted Position |
Subcutaneous (right lower flank region ) |
|
Injected Cell Numbers |
1×10^6/0.1ml |
|
Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hERBB3(HER3)/MC38 Mean Body Weight ± SEM.
2. Tumor Size
Figure 3.hERBB3(HER3)/MC38 Mean Tumor Volume ± SEM .
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
