hCLDN6(Claudin6)/4T1
CBPG0048
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| I. Background | |||
| CLDNs 是上皮细胞紧密连接的主要成分。CLDN6 是紧密连接家族（CLDNs）的一员，是一个四次跨膜蛋白，具有较短的胞质 N 端和 C 端胞质结构域、两个胞外结构域（较大的 ECL1 和较小的 ECL2）和一个短的胞内环。CLDN6 可参与乳腺癌、胃癌、肝细胞癌等多种恶性肿瘤的发生开展。CLDN6 具有重要的生物学功能，其异常表达与丙型肝炎感染有关。 | |||
| II. Introduction | |||
| Host Cell: | 4T1 | ||
| Expressed gene: | hCLDN6(Claudin6) | ||
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
| Freeze Medium: | 90% FBS+10% DMSO | ||
| Culture Medium: | RPMI-1640+10%FBS+2 μg/ml puromycin | ||
| Mycoplasma Testing: | Negative | ||
| Storage: | Liquid nitrogen | ||
| III. Description of Host Cell Line | |||
| Organism: | Mouse | ||
| Tissue: | Mammary gland | ||
| Morphology: | Epithelial | ||
| Growth Properties: | Adherent | ||
| IV. Representative Data | |||
|
Figure 1. Recombinant hCLDN6(Claudin6)/4T1 stably expressing CLDN6. |
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