hIL19/IL20/IL24 Triple Effector Reporter Cell
CBP74223
| I. Background | |
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IL白细胞介素 10（IL-10 ）相关细胞因子家族包括 IL-10、IL-19、IL-20、IL-22、IL-24、IL-26、IL-28A/B 和 IL-29 等几个成员，它们也属于 2α类螺旋细胞因子。IL-19、IL-20、IL- 22、IL-24 和 IL-26 也属于 IL-20 亚家族。IL-20 亚家族是皮肤炎症的核心驱动者（尤以银屑病为典型），同时参与 Th2 疾病（哮喘、AD）及肿瘤微环境调控。 |
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| II. Description | |
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hIL19/IL20/IL24 Triple Effector Reporter Cell 报告基因药靶模型很好的模拟了体内IL19/IL20/IL24 的信号转导过程，原理见下图所示。
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| III. Introduction | |
| Expressed gene: | IL20R1、IL20R2 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin+200 μg/ml Hygromycin B+5 μg/ml Blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
IV. Representative Data Figure 2. Dose Response of Ligands in hIL19/IL20/IL24 Triple Effector Reporter Cell (C16).  Figure 3. Inhibition of Human IL20-induced Reporter Activity by hIL20 Neutralization Ab in hIL19/IL20/IL24 Triple Effector Reporter Cell (C16). |
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