NRAS p.Q61K Reference Standard
CBP10310
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| Introduction | |
| Format | Genomic DNA |
| Description | NRAS Q61K is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). Q61K confers a loss of function on Nras protein as indicated by activation of downstream pathway signaling, increased survival, and transFormation of cultured cells (PMID: 22718121). |
| Technical Data | |
| DNA Change | c.181C>A |
| AA Change | p.Q61K |
| Mutation type | Substitution - Missense |
| Zygosity | Heterozygous |
| Allelic Frequency | 85.71% |
| Transcript | ENST00000369535 |
| Cosmic ID | COSM580 |
| Chr position(GRCh37) | chr1:115256530 |
| Buffer | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | 2-8℃ |
| Expiry | 36 months from the date of manufacture |
